The 2021–22 Serie A de México season is part of the third-tier football league of Mexico.
In the final, if the two teams are tied after both legs, the match goes to extra time and, if necessary, a penalty shoot-out.
Source: Liga Premier FMFNotes:The number listed represents the amount of home matches the club played behind closed doors.
Source: Liga Premier FMF The four best teams of each group play two games against each other on a home-and-away basis.
In the final, if the two teams are tied after both legs, the match goes to extra time and, if necessary, a penalty shoot-out.