The 2020 edition of the tournament was canceled in May 2020 due to the ongoing COVID-19 pandemic in North America.

[1] In the final at Allegiant Stadium, Paradise, Nevada, near Las Vegas, León defeated Seattle Sounders FC 3–2 to win their first title.

The top two Major League Soccer teams from each conference in the 2020 season who did not qualify for the 2021 CONCACAF Champions League qualified for the Leagues Cup.

[2] The top four Liga MX from the 2020–21 season aggregate table who are not competing in the 2021 CONCACAF Champions League semifinals or the 2021 Campeones Cup qualified for the Leagues Cup.

On July 7, 2021, Major League Soccer and Liga MX announced the Leagues Cup schedule as well as the opening round matches.