The 2021 Antalya Challenger IV was a professional tennis tournament played on clay courts.

It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Antalya, Turkey between 6 and 12 December 2021.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: