The 2021 Open International de Tennis de Roanne was a professional tennis tournament played on indoor hard courts.

It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Roanne, France between 8 and 14 November 2021.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: The following players received entry as lucky losers: