The 2021 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo.

It was the 16th edition of the tournament for the men which was part of the 2021 ATP Challenger Tour.

[1] It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between November 8 and 14, 2021.

The 2020 edition could not take place due to the COVID-19 pandemic.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: