The 2021 Tenerife Challenger was a professional tennis tournament played on hard courts.

It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Tenerife, Spain between 1 and 7 November 2021.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: