The 2021 Bank of America Roval 400 was a NASCAR Cup Series race held on October 10, 2021, at Charlotte Motor Speedway in Concord, North Carolina.

In the summer of 2019, the bus stop on the backstretch was changed and deepened, becoming a permanent part of the circuit, compared to the previous year where it was improvised.

07 car suffered catastrophic front end damage from one set of strips during the Xfinity race earlier that day.

Rick Allen, Jeff Burton, Steve Letarte and Dale Earnhardt Jr. called the race from the broadcast booth.

Voice of the Indianapolis 500 Mark Jaynes was assigned the action from the Bank of America bridge to the middle of the infield section.