The 2021 Coca-Cola 600, the 62nd running of the event, was a NASCAR Cup Series race held at Charlotte Motor Speedway in Concord, North Carolina.

The race was held at Charlotte Motor Speedway, located in Concord, North Carolina.

The speedway was built in 1959 by Bruton Smith and is considered the home track for NASCAR with many race teams based in the Charlotte metropolitan area.

Austin Dillon was the fastest in the practice session with a time of 29.845 seconds and a speed of 180.935 mph (291.187 km/h).

Jamie Little, Regan Smith and Vince Welch reported from pit lane during the race.