Contested over 62 laps on the 4.048-mile (6.515 km) road course, it was the 20th race of the 2021 NASCAR Cup Series season.

In June 2020, it was reported that Road America was in negotiations to host the Cup Series in 2021.

When NASCAR revealed the 2021 Cup Series schedule on September 30, 2020, Road America was included on the Fourth of July weekend.

"[10] Kurt Busch was the fastest in the practice session with a time of 2:13:849 seconds and a speed of 108.875 mph (175.217 km/h).

Rick Allen, Jeff Burton, Steve Letarte and Dale Earnhardt Jr. called the race from the broadcast booth.