The 2021 GEICO 500 was a NASCAR Cup Series race was held on April 25, 2021, at Talladega Superspeedway in Lincoln, Alabama.

A tri-oval, the track was constructed in 1969 by the International Speedway Corporation, a business controlled by the France family.

Denny Hamlin was awarded the pole for the race as determined by competition-based formula.

Mike Joy, six-time Talladega winner – and all-time restrictor plate race wins record holder – Jeff Gordon and two-time Talladega winner Clint Bowyer called the race from the broadcast booth.

Steve Post, Dillon Welch and Kim Coon worked pit road for the radio side.