The 2021 YellaWood 500 was a NASCAR Cup Series race held on October 4, 2021, at Talladega Superspeedway in Lincoln, Alabama.

The track is a tri-oval and was constructed in the 1960s by the International Speedway Corporation, a business controlled by the France family.

Denny Hamlin was awarded the pole for the race as determined by competition-based formula.

Rick Allen, Jeff Burton, Steve Letarte and six-time Talladega winner Dale Earnhardt Jr. called the race from the broadcast booth.

Steve Post, Kim Coon, and Hannah Newhouse called the action for MRN from pit lane.