The 2021 Emilia Romagna motorcycle Grand Prix (officially known as the Gran Premio Nolan del Made in Italy e dell'Emilia-Romagna) was the sixteenth round of the 2021 Grand Prix motorcycle racing season.

Sky Racing Team VR46, which usually wears black and blue livery, has now completely changed to yellow with Grazie Vale writing on the side of the bike.

This was done as a form of respect for Valentino Rossi who decided to retire at the end of the 2021 season.

[1] In the MotoGP class, Fabio Quartararo became the first French rider to win the MotoGP World Championship after main rival Francesco Bagnaia crashed out of the lead with five laps to go therefore clinching the championship with two grand prix remaining in the season.

Below are the standings for the top five riders, constructors, and teams after the round.