2021 Motorcycle Grand Prix of the Americas

The event returned after a one-year absence due to the COVID-19 pandemic.

It was originally scheduled for 18 April, but was postponed on 22 January along with the Argentine Grand Prix due to travel restrictions related to the COVID-19 pandemic, and was replaced by the Portuguese Grand Prix.

[1] On 23 June, the event was rescheduled for 3 October following the cancellation of the Japanese Grand Prix.

The race was later restarted over 5 laps but red-flagged again due to an accident involving multiple riders.

The race was not restarted, final results were determined by the first part and full points were awarded.