The 2021 NCAA Division I Women's Swimming and Diving Championships were contested from March 17-20, 2021 at the Greensboro Aquatic Center in Greensboro, North Carolina at the 39th annual NCAA-sanctioned swim meet to determine the team and individual national champions of Division I women's collegiate swimming and diving in the United States.

Hosted by the NC State Wolfpack of North Carolina State University and the Greensboro Sports Foundation, the meet was the first NCAA Swimming & Diving Championship to be held since 2019, after the 2020 meet was canceled due to the COVID-19 pandemic.

Stringent guidelines were imposed at the meet to comply with public health standards in the face of the continuing pandemic.

[1] The Virginia Cavaliers won the meet-- their first NCAA Swimming & Diving title and also the first in the Atlantic Coast Conference.

Todd DeSorbo of Virginia was named the CSCAA Women's Team Coach of the Year and Minnesota's Wenbo Chen was named the Women's Diving Coach of the Year.