The 2021 NCAA Division I Wrestling Championships took place from March 18–20, 2021, in St. Louis, Missouri at the Enterprise Center.

The tournament was the 90th NCAA Division I Wrestling Championship, following the cancellation of the 2020 edition, and featured 63 teams across that level.

[3] Due to the same reason, the Ivy League was unable to compete through the season, leaving out notable teams like Cornell and Princeton, therefore notable wrestlers such as two-time NCAA champion Yianni Diakomihalis and returning All-American Vito Arujau.

[5][2] Little Rock made its NCAA tournament debut with one national qualifier, while it was also the last year for Stanford and Fresno State.

[6][7] Shane Griffith became the second ever NCAA champion from Stanford, and as a response to the cut of the school's wrestling team (Stanford eventually decided to keep the program), he wore a black singlet with no logo during the finals match, and was named the Outstanding Wrestler afterwards.