The tournament's Frozen Four – the semifinals and finals – was hosted by Robert Morris University at the PPG Paints Arena in Pittsburgh from April 8 to 10.

[1] The SNHU Arena in Manchester, New Hampshire, was selected to host the Northeast Region, but pulled out on January 26, 2021, due to concerns over the COVID-19 pandemic.

[3] This year's tournament featured, as of 2024, the longest game in NCAA Division I men's ice hockey tournament history, when the Minnesota Duluth Bulldogs defeated the North Dakota Fighting Hawks by a score of 3–2 in five overtimes, totaling 142:13 minutes of play, in the West Regional Final.

First, it was just the second time in NCAA Division I men's ice hockey tournament history in which three of the final four teams came from one state.

Once seeds were determined, matchups were adjusted to prevent teams from the same conference meeting in the first round, as well as minimize the amount of traveling required due to the pandemic.

[8] As a result, their matchup with Boston College was ruled a no-contest and the Eagles automatically advanced to the Northeast Regional Final.

* denotes overtime period† Michigan and Notre Dame were removed from the tournament due to positive COVID-19 test results.