The Irish played their home games at Frank Eck Stadium as a member of the Atlantic Coast Conference.

The 2020 Notre Dame Fighting Irish baseball team notched a 11–2 (3–0) regular season record.

During the 2021 regular season, Notre Dame finished with a record of 30–11 (25–10 in conference play) and won the ACC Atlantic Division.

[citation needed] The Irish advanced to the Starkville Super Regional, where they lost to Mississippi State.

Niko Kavadas set a program single-season home run record with 21, breaking Frank Jacobs' 1991 total.