The Redblacks were eliminated from postseason contention following their week 10 loss to the Hamilton Tiger-Cats on October 23, 2021.

[4][5] On June 15, 2021, the league released the revised 14-game schedule with regular season play beginning on August 5, 2021.

[11] Due to the shortening of the season, the CFL confirmed that pre-season games would not be played in 2021.

[6] [12] The Redblacks initially had a schedule that featured 18 regular season games beginning on June 11 and ending on October 29.

[4] However, due to the COVID-19 pandemic in Canada, the Canadian Football League delayed the start of the regular season to August 5, 2021 and the Redblacks began their 14-game season on August 7, 2021.