The 2021 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2021 NCAA Division I FCS football season.

Led by eighth-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 4–7 with a mark of 4–2 in conference play, tying for second place in the OVC.

Southeast Missouri State played home games at Houck Stadium in Cape Girardeau, Missouri.

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