The Green Wave played their home games at Yulman Stadium in New Orleans, Louisiana, and competed in the American Athletic Conference.

Prior to the Famous Idaho Potato Bowl in December 2020, offensive coordinator Will Hall accepted the head coaching role at Southern Miss.

[1] On December 10, Fritz announced the firing of defensive coordinator Jack Curtis.

[3] In March 2021, it was announced that Chris Watt would be the offensive line coach for Tulane.

at Vaught–Hemingway Stadium • Oxford, MS *Originally scheduled to kickoff at 7:00 p.m. CST but was delayed due to inclement weather.