The 2021 UC Irvine Anteaters baseball team represented the University of California, Irvine during the 2021 NCAA Division I baseball season.

The Anteaters played their home games at Anteater Ballpark as a member of the Big West Conference.

They were led by third-year head coach Ben Orloff.

The 2020 UC Irvine Anteaters baseball team notched a 8–7 (0–0) regular-season record.

The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.