The 2021 Wake Forest Demon Deacons baseball team represented Wake Forest University during the 2021 NCAA Division I baseball season.

The Demon Deacons play their home games at David F. Couch Ballpark as a member of the Atlantic Coast Conference.

They were led by head coach Tom Walter in his 12th season at Wake Forest.

Pitchers Catchers Infielders Outfielders ^ Collegiate Baseball ranked 40 teams in their preseason poll, but only ranked 30 teams weekly during the season.† NCBWA ranks 35 teams in their preseason poll, but only ranks 30 teams weekly during the season.

* A new poll was not released for this week, so for comparison purposes, the previous week's ranking is inserted in this week's slot.