The 2022–23 season was the 70th season in the history of CD Lugo and their 11th consecutive season in the second division.

The club participated in Segunda División and the Copa del Rey.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Fixtures Source: Soccerway Notes Source: LaLiga SmartBank The league fixtures were announced on 23 June 2022.