The Cardinals were led by coach Jeff Dow, in his fourth season, and were members of the Southland Conference.

Winning the regular season head-to-head with Northwestern State, the Cardinals entered the 2022 Southland Conference women's basketball tournament as the No.

They received the conference's automatic bid to the 2022 NCAA Division I women's basketball tournament.

Their season ended in the opening game of the NCAA tournament with a 51–55 loss to Howard University.

Receiving 64 votes overall, the Cardinals were picked to finish seventh in the conference.