The 2022 Caldas da Rainha Ladies Open was a professional tennis tournament played on outdoor hard courts.

It was the third edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Caldas da Rainha, Portugal between 12 and 18 September 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: