The 2022 Vrnjačka Banja Open was a professional tennis tournament played on outdoor clay courts.

It was the tenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Vrnjačka Banja, Serbia between 19 and 25 September 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following player received entry into the singles main draw as a special exempt: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: