The 2022 Empire Women's Indoor 2 was a professional tennis tournament played on indoor hard courts.

It was the tenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Trnava, Slovakia between 10 and 16 October 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a junior exempt: The following players received entry from the qualifying draw: The following players received entry as Lucky Losers: