[2] The draw for the third round was held on 28 March 2022, 15:00 at CBF headquarters in Rio de Janeiro.
[3] In a first draw, the 32 teams, seeded by their CBF ranking, were drawn into 16 ties.
If the aggregate score was level, the second-leg match would go straight to the penalty shoot-out to determine the winners.
Tied 1–1 on aggregate, Atlético Goianiense won on penalties and advanced to the round of 16.
Tied 1–1 on aggregate, Bahia won on penalties and advanced to the round of 16.