Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

The draw for the group stage was held on 25 March 2022, 12:00 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.

The draw for the round of 16 was held on 27 May 2022, 12:00 PYST (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

The draw for the round of 16 was held on 7 June 2022 at CBF headquarters in Rio de Janeiro.

Palmeiras qualified for the 2022 Recopa Sudamericana by winning the 2021 Copa Libertadores.