In addition to the Campeonato Brasileiro Série B, Grêmio participates in this season's editions of the Copa do Brasil, the Campeonato Gaúcho, and the Recopa Gaúcha.

The season covers the period from 26 January 2022 to 6 November 2022, a shorter season due to the 2022 FIFA World Cup.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Soccerway The league fixtures were announced on 3 February 2022.

[3] The draw for the first round was held on 17 January 2022, 13:00 UTC−03:00, at the CBF headquarters in Rio de Janeiro.