Source: SantosFC.com.br (for appearances and goals), Wikipedia players' articles (for international appearances and goals), FPF (for contracts).

Players in italic were not registered for the Campeonato Paulista.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Santos FC Source: Match reports in Competitive matches, Soccerway Source: Match reports in Competitive matches Source: Match reports in Competitive matches = Number of bookings;   = Number of sending offs after a second yellow card; = Number of sending offs by a direct red card.

The draw for the final stage was held on 27 May 2022.