In the MotoGP class, the presence of two wildcards in the entry list of the race should be noted: Lorenzo Savadori, in his second consecutive race after the Portuguese Grand Prix, and Stefan Bradl, who had already replaced Marc Márquez in the Repsol Honda Team in the Grand Prix of Argentina.

In the Moto2 class, Stefano Manzi replaces Keminth Kubo in the Yamaha VR46 Master Camp Team, following the diagnosis of costochondritis found on the Thai rider after FP1.

In the MotoE class, which debuts in this Grand Prix, Bradley Smith of the WithU GRT RNF MotoE Team, following the crash at the 24 Hours of Le Mans, he is forced to give up this stage and is replaced by Lukas Tulovic,[2][3] while the Spanish rider Yeray Ruiz replaces the starting rider Xavi Cardelús in the Avintia Esponsorama Racing, absent due to injury.

[4] Fabio Quartararo, winner of the Portuguese Grand Prix, and Álex Rins lead the riders' standings with 69 points, 3 more than Aleix Espargaró, 8 more than Enea Bastianini (previous leader) and 18 more than Johann Zarco.

Aspar Team overtakes Leopard Racing at the top of the team standings (131 points for the first, 109 for the second); Red Bull KTM Ajo is third with 70 points, 2 more than CFMoto Racing Prüstel GP and 13 more than Red Bull KTM Tech3.

In the fourth session, Francesco Bagnaia was the fastest ahead of Fabio Quartararo and Joan Mir.