The 2022 Grand Est Open 88 was a professional women's tennis tournament played on outdoor clay courts.

It was the fifteenth edition of the tournament and first ever as a WTA 125 event, which is also part of the 2022 WTA 125 tournaments.

It took place in Contrexéville, France between 4 and 10 July 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following pair received a wildcard into the doubles main draw: