The 2022 Karlsruhe Open (also known as the Liqui Moly Open for sponsorship reasons) was a professional tennis tournament played on outdoor clay courts.

It was the 3rd edition of the tournament and part of the 2022 WTA 125 tournaments, offering a total of $115,000 in prize money.

It took place in Karlsruhe, Germany between 10 and 15 May 2022.

[1] The following players received a wildcard into the singles main draw: The following players received entry into the singles main draw through protected ranking: The following pair received a wildcard into the doubles main draw: