The 2022 L'Open 35 de Saint-Malo was a professional tennis tournament played on outdoor clay courts.

It was the twenty-seventh edition of the tournament and a part of the 2022 WTA 125 tournaments.

It took place in Saint-Malo, France between 2 and 8 May 2022.

[1] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: