Moreno ran on a platform highlighting his track record in Manila and promising to replicate his 3-year achievements as first-termed mayor on a national scale.

He also vowed to lower utility expenses and continue certain policies of then incumbent President Rodrigo Duterte such as infrastructure development and the campaign against illegal drugs while maintaining adherence to human rights.

His campaign has been observed to have been affected by his lack of political machinery, minimal media coverage, and insufficient counter to overwhelming disinformation against him.

Born and raised in the slums of Tondo, Manila, Isko Moreno first gained popularity as a cast member of the variety show That's Entertainment during the 1990s.

Isko Moreno was reportedly to take his oath as a member of Aksyon Demokratiko, the party founded by Senator Raul Roco, in September 2021.

[19] According to Ong in an interview with Boy Abunda in April 2022, there was a supposed backdoor "unity talk" among Moreno, incumbent Vice President Leni Robredo and other aspirants before the filing of candidacy.

The initial plan was for these camps to form a united front to avoid vote splitting against former senator Bongbong Marcos who also hinted to run for presidency, but the scheduled meeting did not push through.

[24] On October 13, 2022, it was announced that Moreno's long-time aide and chief of staff Cesar Chavez, a former Department of Transportation undersecretary and known ally of political bigwigs, amicably resigned from his post after he was offered a promotion from his previous job at DZRH and due to health concerns despite rumors of "infighting" between Banayo's team and Moreno's long-time supporters including Chavez.

[7] The song Ganon Paren To by hip-hop artist Bugoy na Koykoy, who first popularized the term "2 joints" in the Philippines, was later used in Moreno's campaign rallies after securing permission.

Moreno also prided himself as the only candidate who acts and gets things done swiftly, citing his universally-acclaimed accomplishments as mayor in just three years time on his first term.

Campaign events in the region notably featured local officials pushing for a Moreno and Sara Duterte (ISSA) tandem.

[42][43][44] Moreno had maintained his standing as the "top second choice" of voters based on surveys conducted by pollsters Pulse Asia, OCTA Research, and Manila Bulletin–Tangere months before the election.

[153] Moreno also expressed interest to include then incumbent President Rodrigo Duterte in his slate, had he decided to pursue his initial intention to run for senator, despite the two having a fall-out months prior to the filing of candidacy.

[279] Moreno is also in favor of ending contractualization but wants the government to increase employment rate first by generating as many jobs as possible before considering such action.

[281][282] Moreno is in favor of legally penalizing social media sites promoting fake news, disinformation, and misinformation, reiterating his stance as "non-negotiable".

[283][284] Moreno has said that he admired former President Ferdinand E. Marcos Sr. "at some point", specifically for being a "visionary" and for his infrastructure projects, but condemns his links to corruption and human rights abuses.

On the issue of the country's claim to the West Philippine Sea occupied by Chinese forces, he believes that the Philippines' approach should be "fearless" in asserting the claim and should be responsive to the plight of Filipino fishermen, while at the same time should be "fair" and "sensible" in dealing with other countries also occupying the South China Sea, especially in trade.

Moreno has criticized the United Nations (UN), questioning what they are doing in light of China's disregard of the Permanent Court of Arbitration (PCA).

Moreno asserted that China needs to accept a 2016 arbitration award of the Hague ruling that made clear the Philippines' entitlements, including where it can fish and exploit offshore oil and gas, also citing the Velarde map as reference.

[290][291][292] Moreno expressed support of the Philippines returning to the International Criminal Court (ICC) if the move would "give a good impression to the world".

[293] Moreno is in favor that all government officials should be open to disclosing their Statement of Assets, Liabilities, and Net Worth (SALN), including "their properties, belongings and their debts", being a public document.

[294][295] Moreno expressed the idea to invest in local human resources such as doctors and scientists to make locally-made medicines, even a vaccine, in addressing the COVID-19 pandemic in the Philippines.

He vows to continue the program and plans to impose a well-planned zoning by making the National Land Use Act a priority legislation.

[301] Moreno is in favor of entering bilateral labor agreement with other countries to ensure the welfare of both documented and undocumented Overseas Filipino Workers (OFW).

He is vocal about providing equal opportunities to women, regardless of social status, sexual preference, religious beliefs or political affiliations.

He is also an advocate of meritocracy and favors job promotions based on merits and credentials and not by political affiliations and gender as what he did in the Manila City Hall during his term as mayor.