The Democratic Party made historic gains, taking full control of state government for the first time since 1983 and marking a point where Democrats held all four elected statewide offices, both U.S. Senate seats, and both chambers of the Michigan Legislature.

Incumbent Democratic secretary of state Jocelyn Benson won re-election against Republican Kristina Karamo by a margin of 14%.

Incumbent Democratic attorney general Dana Nessel won re-election against Republican Matthew DePerno by a margin of 8.6%.

Just weeks after the election, Michigan governor Gretchen Whitmer appointed Kyra Harris Bolden to the Supreme Court to replace Bridget Mary McCormack, who stepped down.

Issues occurred in a few locations with part of the Ottawa County Clerk's office losing power and requiring a backup generator,[13] due to an error involving a construction crew that was working on nearby power lines,[14] precincts in Ada Township temporarily running out of ballots,[15] tabulator jams in Kent County due to ballots being marked in pen that had not dried,[16][17] and long lines as polls were closing at City Hall in Grand Rapids.