[2] It served as a selection meet for determining the swimmers to represent South Africa at the 2022 World Aquatics Championships and 2022 Commonwealth Games.
[5] Key: Highlighted swimmers achieved the "A" qualifying time for the 2022 World Aquatics Championships and the 2022 Commonwealth Games in the event.
[6][7] Highlighted swimmers achieved a "B" qualifying time and were named to the 2022 World Aquatics Championships roster for South Africa in the event.
[11][10][13][9][14] Aired broadcasts were continuous stream format, meaning they covered heats through finals, and were segmented into two videos if exceeding 12 hours in length.
[4] On the morning of the last day of competition, Monday 11 April 2022, 45-year-old security guard Monde Qheru was found dead in the Newton Park Swimming Pool.