South Africa competed at the 2022 Commonwealth Games in Birmingham, England from 28 July to 8 August 2022.

Para-swimmer Christian Sadie and netballer Bongiwe Msomi were the country's flagbearers during the opening ceremony.

[9] Luxolo Adams and Shaun Maswanganyi pulled out of the squad after suffering injuries in the World Athletics Championships.

[10][11] Sprinters Clarence Munyai and Emile Erasmus, pole vaulter Kyle Rademeyer and 400m runner Zakhiti Nene had to withdraw due to displaying COVID-19 symptoms.

As of 1 June 2022, South Africa qualified for the mixed team event via the BWF World Rankings.

[7][8] By virtue of its position in the ICC Women's T20I rankings (as of 1 April 2021), South Africa qualified for the tournament.

[9] By virtue of their position in the FIH World Rankings for men and women respectively (as of 1 February 2022), South Africa qualified for both tournaments.

[33] Reserves: Kayla de Waal, Charné Maddocks, Kirsty Adams, Sylvia van Jaarsveld & Mathaphelo Ramasimong

[34][8] By virtue of its position in the World Netball Rankings (as of 28 July 2021), South Africa qualified for the tournament.

[7][8] South Africa qualified four weightlifters (three men, one woman) via the IWF Commonwealth Ranking List, which was finalised on 9 March 2022.