The team also released several veterans such as center Mitch Morse, cornerback Tre'Davious White, and safety Jordan Poyer, several players who had been key contributors during the McDermott era, among others.

The Cardinals had one last chance to win after the Bills expanded their lead to 34–28, but quarterback Kyler Murray's last second Hail Mary pass attempt was denied by Bills cornerback Ja'Marcus Ingram, preventing a repeat of the Hail Murray from the 2020 season.

The Bills cruised to a 31–10 win over the rival Dolphins, thanks to three total touchdowns by running back James Cook and the defense intercepting Miami quarterback Tua Tagovailoa three times.

Buffalo's defensive line only allowed Jacksonville a field goal and a touchdown in the game, with Bills safety Damar Hamlin picking off Jaguar quarterback Trevor Lawrence for his first interception.

Davis' fellow halfbacks James Cook and Ty Johnson also scored touchdowns as the Bills improved their record to 3–0.

With the defense missing several key players due to ongoing injuries, they were unable to contain Baltimore running back Derrick Henry as he rushed for 199 yards.

However, in what was seen as a major gaffe, the Bills opted to pass three consecutive times from their own end zone with just seconds left in regulation, resulting in three incompletions from Josh Allen, who finished with a career-worst 30% completion percentage.

After suffering back-to-back losses, the Bills started this Monday Night Football game against the division rival Jets with a strong rushing attack, despite missing starting tailback James Cook due to a toe injury, and Josh Allen scoring three touchdowns in the first half, namely a one-yard rushing touchdown and scoring passes to Mack Hollins and Dawson Knox.

The defense struggled to contain Aaron Rodgers and Breece Hall at times, despite the returns of cornerback Taron Johnson and safety Taylor Rapp, culminating in the Jets keeping the score close, with Rodgers throwing a 52-yard Hail Mary pass to Allen Lazard as time expired in the first half.

During a low-scoring second half, Bills kicker Tyler Bass kicked a go-ahead field goal with just three minutes to go, and Rodgers was intercepted by Johnson on the ensuing drive, sealing Buffalo’s fourth win in the 2024 season.

All three of Buffalo's active halfbacks, namely James Cook, Ty Johnson, and Ray Davis, scored touchdowns, in addition to newly-acquired receiver Amari Cooper.

The Bills opened the scoring in their second regular-season meeting with the Dolphins, with Tyler Bass making a 40-yard field goal.

The Dolphins took advantage of Josh Allen's second interception of the season, where a pass intended for Keon Coleman bounced off of the receiver's hands and was picked off by Miami cornerback Jalen Ramsey on the 3-yard line.

The Dolphins received the kickoff to start the second half, but their first drive ended in a forced fumble by Taron Johnson, with Kaiir Elam recovering the ball for the Bills.

The Bills started this matchup against the Colts with a pick six by Taron Johnson, who intercepted a pass from Indianapolis backup quarterback Joe Flacco, and a 29-yard Tyler Bass field goal.

Taylor Rapp picked off a pass thrown by Patrick Mahomes as he was being tackled by DaQuan Jones, and the Bills capitalized on the takeaway with an 8-play, 65-yard drive to go up 6–0.

The Chiefs took advantage of a miscue to make it 14–13 after picking off Josh Allen, and the Bills ended the first half with a 33-yard field goal to bring the score to 16–14.

After trading punts on the first four plays of the second half, the Bills held onto the ball for 6:03 on their longest touchdown drive of the game, putting them two scores ahead of the Chiefs at 23–14.

Facing 4th & 2 on the Chiefs' 26 yard line, Josh Allen took control of the game and brought his team to 30–21 with a 26-yard rushing touchdown.

Following a hard loss the week prior, Buffalo utilized their strong rushing attack in game to gain multiple points.

To finish it off, Taron Johnson narrowly recovered an onside kick with twelve seconds left in the game, giving the Bills the win.

After earning an explosive win the previous week, Buffalo began their first meeting of the season against their division rival sluggishly, as both the offense and defense struggled against New England.

In addition to this, Allen became the first quarterback in NFL history with 40+ touchdowns in five consecutive seasons, while Cooper eclipsed 10,000 receiving yards across his career.

After a Week 4 regular season meeting resulting in one of their worst losses in recent years, Buffalo went into the Divisional Round as the rare home team underdogs.

The Bills would answer back in the first half with three rushing touchdowns: one by Ray Davis and two by Josh Allen, with the Ravens only scoring a field goal in return.

However, the second half would feature the Ravens nearly making a comeback as they would outscore the Bills, with the latter only scoring two field goals by Tyler Bass to answer back.

In the end, the Ravens scored a touchdown to make it a 27–25, but failed the 2-point conversion attempt due to Mark Andrews dropping the ball.

The Chiefs would get the ball at midfield as Patrick Mahomes's 10-yard run brought the lead back and successfully converted 2 points, making it 29–22 Kansas City.

Following the warning, the Bills' offensive line was not able to contain the Chiefs defenders rushed to Josh Allen, pressuring him to throw the ball.

The ball slightly landed in the hands of Dalton Kincaid, but dropped it, thus sealing the game in favor of Kansas City.