The 2025 Eastern Illinois Panthers football team will represent Eastern Illinois University as a member of the OVC–Big South Football Association during the 2025 NCAA Division I FCS football season.

The Panthers were led by fourth-year head coach Chris Wilkerson and play their home games at O'Brien Field located in Charleston, Illinois.

[1][2][3][4] [5][6] [7] at O'Brien Field • Charleston, IL at Memorial Stadium • Terre Haute, IN at Memorial Stadium • Champaign, IL at Hanson Field • Macomb, IL at O'Brien Field • Charleston, IL at O'Brien Field • Charleston, IL at Houck Stadium • Cape Girardeau, MO at Buccaneer Field • North Charleston, SC at O'Brien Field • Charleston, IL at O'Brien Field • Charleston, IL at Harlen C. Hunter Stadium • St. Charles, MO at Bryant–Denny Stadium • Tuscaloosa, AL