The 2025 Tennessee State Tigers football team will represent Tennessee State University as a member of the OVC–Big South Football Association during the 2025 NCAA Division I FCS football season.

The Tigers are expected to be led by fifth-year head coach Eddie George, and play their home games at Nissan Stadium in Nashville, Tennessee.

[1][2][3][4] [10] at Hale Stadium • Nashville, TN at Nissan Stadium • Nashville, TN at Nissan Stadium • Nashville, TN at O'Brien Field • Charleston, IL at Houck Stadium • Cape Girardeau, MO at Hale Stadium • Nashville, TN at Nissan Stadium • Nashville, TN at Nissan Stadium • Nashville, TN at Graham Stadium • Martin, TN at Nissan Stadium • Nashville, TN at Buccaneer Field • North Charleston, SC