The 2025 Southeast Missouri State Redhawks football team will represent Southeast Missouri State University (SEMO) as a member of the OVC–Big South Football Association during the 2025 NCAA Division I FCS football season.

They are expected to be led by 12th-year head coach Tom Matukewicz.

The Redhawks play their home games at Houck Stadium in Cape Girardeau, Missouri.

[1][2][3][4] [4] [5] at Centennial Bank Stadium • Jonesboro, AR at Houck Stadium • Cape Girardeau, MO at Fargodome • Fargo, ND at Houck Stadium • Cape Girardeau, MO at Graham Stadium • Martin, TN at Houck Stadium • Cape Girardeau, MO at Houck Stadium • Cape Girardeau, MO at Tucker Stadium • Cookeville, TN at Houck Stadium • Cape Girardeau, MO at Ernest W. Spangler Stadium • Boiling Springs, NC at Hanson Field • Macomb, IL at Houck Stadium • Cape Girardeau, MO