The regiment served in the Puerto Rico campaign.

[2] They proceeded to Camp Thomas, near the old Chickamauga battlefield in Tennessee, to prepare for battle in the Caribbean.

They occupied the cities of Ponce and Coamo, and engaged in skirmishing in that area until the cessation of hostilities in August.

[3] At the time of mustering out, the unit consisted of 48 officers and 1,248 enlisted men.

[2] The 2nd Wisconsin Infantry suffered 39 enlisted men who died of disease, plus 5 additional men who were discharged for disability, court martial, or other causes, and 1 desertion.