In enzymology, a 3-oxoacid CoA-transferase (EC 2.8.3.5) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are succinyl-CoA and 3-oxo acid, whereas its two products are succinate and 3-oxoacyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases.

The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase.

This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies,[1] valine, leucine and isoleucine degradation, and butanoate metabolism.

[2] As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1M3E, 1O9L, 1OOY, 1OOZ, 1OPE, 2NRB, and 2NRC.