In enzymology, a 4-hydroxybenzoate—CoA ligase (EC 6.2.1.27) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases.
The systematic name of this enzyme class is 4-hydroxybenzoate:CoA ligase (AMP-forming).
Other names in common use include 4-hydroxybenzoate-CoA synthetase, 4-hydroxybenzoate-coenzyme A ligase (AMP-forming), 4-hydroxybenzoyl coenzyme A synthetase, and 4-hydroxybenzoyl-CoA ligase.
This enzyme participates in benzoate degradation via coa ligation.