[citation needed] On the night of 10-11 March 2022, in the village of Orlove [uk], Kherson Oblast, Russian reconnaissance units killed a member of the 60th Brigade and captured two others, later killing them in the village of Mariine [uk].

During the day on 11 March, an additional five soldiers of the 60th Brigade were killed in combat near Orlove, but the Ukrainian forces reportedly managed to stop the advance of a Russian column.

[5] By the end of March 2022, it was announced that the brigade, alongside the 4th Battalion of the 17th Tank Brigade, had taken part in the recapture of eleven settlements in the northern portion of the Kherson Oblast, including Orlove and Novovorontsovka.

[6][7] A battalion of the 60th Brigade, along with a battalion from Ukraine's 128th Brigade, conducted an offensive operation in October 2022 forcing Russian troops to retreat from parts of the Kherson Oblast west of the Dnieper River towards the villages of Dudchany and Mylove.

[8] The brigade fought in the battle of Bakhmut to the point of exhaustion and were noted by the Washington Post as having low morale.