The brigade was re-raised on 1 March 2010 to oversee the Army's command support and intelligence, surveillance, target acquisition and reconnaissance (CS & ISTAR) units.

[3][4] After being sent to Egypt in June 1915 with the 2nd Division as part of an expansion of the Australian Imperial Force, the brigade was sent to Gallipoli in September, however, as the last Allied offensive had come to an end the previous month, from then up until December 1915 when the Anzacs were evacuated from the peninsula, the brigade was not involved in any significant engagements.

[5] In 1920, following the re-organisation of the Citizens Military Force (CMF), the 6th Brigade became part of the 4th Infantry Division, encompassing units drawn from Victoria and South Australia.

In early 1942, the 7th and 8th Battalions were detached to Darwin, Northern Territory, and the brigade was moved to Gherang to form part of the Army Headquarters Reserve; the 17th Light Horse and 4th Armoured Regiments were detached at this time, and the 48th Battalion was gained from South Australia.

[11][12][13] Based in Buna, in Papua, they carried out garrison duties as well as patrols around the areas surrounding Milne and Nassu Bay.

[11] In November 1944, the 14th/32nd Battalion and other elements of the brigade landed at Jacquinot Bay, where the 5th Division's main logistics base was to be constructed.

In mid-March, they came up against the main Japanese defensive line in the Waitavalo–Tol Plantation around Bacon Hill and over the course of two days, the 19th Battalion and 14th/32nd fought to capture it.

[11][13] Following this, the 6th Brigade established a defensive line that extended across the Gazelle Peninsula, and from there they continued to mount patrols into Japanese held-territory until April 1945 when they were withdrawn back to Australia.

[11] Although it was originally planned that the brigade would re-organise to make up its losses and begin training for participation in further operations, as the war in the Pacific wound down, the decision was made disbanded the 6th Brigade and a number of its component units in July 1945 as part of the demobilisation process.

During this time brigade formations were discontinued, although their headquarters units remained in many cases, to improve the flow of information.

Its headquarters is located at Victoria Barracks, Sydney and it forms part of the Army's Forces Command.