The 6th Tennessee Infantry was organized at Williamsburg and Boston, Kentucky and mustered in for a three-year enlistment on April 18, 1862.

The regiment was attached to 25th Brigade, 7th Division, Army of the Ohio, to October 1862.

1st Brigade, District of West Virginia, Department of the Ohio, to November 1862.

1st Brigade, 2nd Division, Center, XIV Corps, Army of the Cumberland, to January 1863.

3rd Brigade, 3rd Division, XXIII Corps, Army of the Ohio, to August 1863.

3rd Brigade, 3rd Division, Reserve Corps, Army of the Cumberland, to October 1863.

Spear's Tennessee Brigade, 2nd Division, XXIII Corps, to January 1864.

3rd Brigade, Rousseau's 3rd Division, XII Corps, Department of the Cumberland, to April 1864.

1st Brigade, 2nd Division, XXIII Corps, Army of the Ohio, to February 1865.

1st Brigade, 2nd Division, XXIII Corps, Department of North Carolina, to May 1865.

Evacuation of Cumberland Gap and retreat to Greenupsburg, Ky., September 17-October 3.

Near Gallipolis, Ohio, and operations in the Kanawha Valley, W. Va., until November.

Action at Missionary Ridge and Shallow Ford Gap September 22.

Duty near Knoxville and operations in eastern Tennessee until April 1864.

Operations on Pumpkin Vine Creek and battles about Dallas, New Hope Church, and Allatoona Hills May 2-June 5.

Relieved for muster out March 31, and ordered to Nashville, Tenn.