He enrolled at Louisiana State University and starred as defensive tackle for the Tigers with an All-SEC and All-Academic honors.

In the 1982 AFC Championship game, Duhe intercepted Richard Todd three times as the Dolphins defeated the New York Jets 14–0.

He returned the third interception 35 yards for a touchdown in the fourth quarter to seal Miami's trip to Super Bowl XVII.

His last season saw the Dolphins reach Super Bowl XIX (with him starting eight games and playing in four others due to grueling workouts from him), but he played for only a small portion due to a knee problem that left him unable to move laterally and a shoulder with diminished hitting capacity.

[3] In August 1985, the Dolphins placed him on medical waivers and released (which meant he received just over twenty percent of his planned $275,000 salary).